Sep 302011
 

Lawfare links the newspaper coverage at this post.  Al-Aulaqi was an American-born radical Muslim cleric who had emerged as both a leading voice in Al Qaeda recruiting and propaganda over the internet and, according to the US government, was also involved in operations and operational planning with Al Qaeda in the Arabian Peninsula, an offshoot Al Qaeda terrorist organization that the US governments regards as an “associated force” with Al Qaeda (and hence covered by the terms of the original Authorization to Use Military Force).

When it became public that the Obama administration had put Al-Aulaqi on a target list, the ACLU filed suit on his behalf through his father; it made international law arguments that included the proposition that he was outside of the war zone and hence could only be sought through law enforcement methods, as well as domestic law arguments that this amounted to the execution of a citizen designated by the President without judicial process.  The suit was dismissed in December 2010 by Judge John Bates.

(The newspaper accounts at the Lawfare link give decent background on the court case and background on Al-Aulaqi.  As background academic reading on the issues in this case, see Robert Chesney’s forthcoming Yearbook of International Law article, available at SSRN in draft, “Who May Be Killed: Anwar al-Awlaki as a Case Study.” I will try to add some more links to this post later; for background on the question of the “geography” of armed conflict, see this short essay; for a philosophical argument on whether drones make using force “too easy,” see this essay; and for a short blog post arguing against David Ignatius’ claim that the US is “addicted” to drones, see Opinio Juris, “Tactically Precise, Strategically Incontinent?” )

The government has maintained throughout all this that Al-Aulaqi was deemed a lawful target not on account of his expression of opinions, including calls to violence against the United States and its citizens, but instead on account of his operational involvement in AQAP, in ways going to leadership of an associated force terrorist organization and operational and planning involvement.   My view of this targeted killing is straightforwardly, congratulations, Mr. President.  What has been visible publicly leaves little or no doubt in my mind that Al-Aulaqi was deeply involved in AQAP in operations, and indeed at the highest levels.

Update: I’ve done a couple of phone interviews in the last couple of hours, and thought it might be useful to give a summary version of how I think the US government sees the law and legal policy in this attack.  (This is merely my personal sense of the US government’s legal views, supplemented as indicated by my own views.  I’m not an insider; I have never worked for the US government, and people don’t leak things to me, so this is my attempt to read the US legal position from the outside.)

Who? As an international law matter, is Al-Aulaqi a lawful target? The US government sees him as taking part in hostilities, part of the operational leadership of an associated force with Al Qaeda, the AQAP.  So, yes, he can be targeted with lethal force — and targeted without warning, without an attempt to arrest or apprehend as a law enforcement matter.

Where?  Does it matter that he was in Yemen, and not an “active battlefield” in a conventional hostilities sense? The US government does not accept the idea that the armed conflict with Al Qaeda — or armed conflict generally — is confined as a legal matter to some notion of “theatres of conflict” or “active battlefields” or related terms that have been used in recent years by academics and activist groups.  As I understand the US government position, it sticks by the traditional concept of “hostilities,” and that where the hostiles go, the possibility of armed conflict goes too (I try to explain this evolution of these views in this short essay).  So the fact that he was present in Yemen does not make him beyond targeting, because he is not present in some “active” battlezone such as Afghanistan.

This claim — the conflict follows the participants — frequently leads to a complaint that this means the US might target him in Paris or London.  The US position is that the standard for addressing non-state actor terrorists taking safe haven somewhere depends on whether the sovereign where the terrorist is hiding is “unwilling or unable” to address the threat.  No, there won’t be Predators Over Paris; Yemen or Somalia is another matter, as President Obama has repeatedly and without cavil said in speeches over the last few years.

By whom can he be targeted?  The military or the CIA? US domestic law provides authority for the President to direct either the US military, or the CIA, or both acting together, to undertake the use of force abroad.  In this case, it appears from first reports that the operation was “directed” by the CIA — presumably on account of intelligence roles — and carried out operationally by the military.  As I have said on other occasions (and, heads-up, Robert Chesney is finishing an important new paper on this topic) I think there are important ways in which the legal authorities, oversight and reporting, and other activities associated with an intermingling of CIA and military special operations should be re-examined.  One in particular is some way of recognizing a category of “deniable” operations that are not truly covert.

US citizenship?  What difference, if any, does being a US citizen make? The fact of US citizenship is the factor in this situation that has most excited the blogosphere.  Insofar as Al-Aulaqi was targeted for taking operational part in groups engaged in armed conflict with the United States, historically the fact of citizenship has been neither here nor there.  That’s the easy answer — essentially just asserting the existence of the armed conflict like any other — and as a legal basis for targeting, I think the US government is on solid ground if that’s its claim.  And to reiterate what is said above, the US government has been very careful to rely not upon “internet preacher shooting his mouth off,” but instead on distinct operational roles.  (To be perfectly clear: I myself believe there will eventually be cases of incitement to killing and participation over the internet by radical jihadist preachers that will raise the question of targeting on the basis of incitement alone, and my own view is that there are circumstances where that will be justified, including some who will be US citizens — and in the US government’s view, this is not, repeat not, that case.)

The reality, of course, is that this is not like any other armed conflict, and though I believe the US government had firm grounds domestically and internationally to target Al-Aulaqi, I also believe as a matter of forward looking legal policy that the US should elaborate more extensive and explicit oversight procedures in the case of targeting of US citizens that will ensure the buy-in of the political branches.  It seems clear that this was done informally in the designation of Al-Aulaqi as a target, but I believe this process should be formalized in the secret reporting to Congress.  The courts should, as Judge John Bates did in dismissing the ACLU’s attempt to secure an injunction against targeting Al-Aulaqi, decline to intervene in processes of vital national security abroad in which the political branches have an agreed-upon procedure of oversight and accountability.

As to the due process claims, as Robert Chesney notes at Lawfare, the US government does not appear to be taking a blanket position that a US citizen deemed to be a targetable participant in a terrorist group has no due process rights outside of the US in any sense, on the one hand, but neither does it appear to take the position that the vindication of whatever those due process rights are entitles the citizen to merely being subject to an attempt to arrest, including in a remote location in Yemen, and to warning before using lethal force.  I don’t think the US government has a worked out position suitable for every case — as seems to me quite appropriate.  It is in the process of working out something that is only partly like straight-up armed conflict law and something that is gradually, inchoately emerging as a sort of “state practice” of covert intelligence operations.  The working out of those positions is proceeding case by case.

One thing that does appear quite settled as far as the US government’s position is concerned, however, is that it is simply inapposite to talk about this as “summary execution upon nothing more than the order of the President” — it’s simply not the correct legal frame.  Ben Wittes names a number of these factors in his Lawfare discussion of the process that is due in this matter.  I’d say that among other things, the “summary execution without due process” meme fails to take account of

  • taking up operational roles in armed conflict against the United States;
  • fleeing to places beyond the bounds of law enforcement that might serve to arrest Al-Aulaqi if he had been in the territorial US;
  • the existence of robust domestic legal authorities for undertaking lethal action even against a US citizen (it is not as if this was not understood as a possibility in the Cold War);
  • acknowledgment that the US was willing to consider ways to accepting surrender and coming into custody that would allow judicial review; and
  • a lengthy judicial opinion that refused to take a simplistic view of due process in this very case (in either direction, simply targetable combatant or US citizen denied due process) irrespective of whether one thinks the outcome correct or not.

These and other such circumstances re-draw the caricature offered on some of the blogs of the President taking it into his head to assassinate, using death from the skies, some US citizen who merely happens to be outside the US at that moment.  Whatever the situation is exactly, it is a lot more than that.

Article source: http://feedproxy.google.com/~r/volokh/mainfeed/~3/RTB2hHoPsf8/

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Sep 302011
 


(Medical Xpress) — Researchers at the University of Cincinnati have discovered that the immediate improvement in blood sugar (blood glucose) for those with type 2 diabetes who undergo gastric bypass surgery is related to the increased action of a gut hormone that occurs after the procedure.


These findings, which are featured in the September edition of the journal Diabetes, could eventually help researchers find new treatments for type 2 diabetes, which affects roughly 24 million people in the United States.

“It has been found that improvement for individuals with type 2 diabetes occurs immediately after surgery, even before any happens, but the reason for this glucose improvement is not fully understood,” says Marzieh Salehi, MD, assistant professor in the division of endocrinology, metabolism and diabetes, UC Health physician and lead investigator on this study.

“It is known that in healthy individuals, the secretion of insulin—a hormone regulating glucose levels—is larger when glucose is given orally than intravenously, mainly as a result of the action of two gastrointestinal hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP).”

Salehi adds that these gut hormones are released in response to food intake and increase insulin secretion in proportion of what is eaten.

 ”In this study, we found that the GLP-1 action is enhanced after gastric bypass surgery, and increased GLP-1 action contributes significantly to the increased insulin response to meal ingestion after this procedure, which could lead to glucose improvement in patients with type 2 diabetes.”
 
In the study, researchers analyzed 12 people who previously underwent gastric bypass but did not have and 10 healthy control subjects who did not have the surgery. Gut hormones and insulin secretion response to meal ingestion were compared between the two days of studies, in which one group was a control and the other received a compound blocking the action of GLP-1.
 
“Blocking the action of GLP-1 suppressed insulin secretion to a larger extent in those who had the surgery than in the control subjects,” she says, adding that the exaggerated GLP-1 action to insulin response after meals could be one of the underlying mechanisms by which gastric bypass alters glucose metabolism without weight loss.

Salehi says researchers also found that another important hormone in glucose metabolism, glucagon, is increased after gastric bypass surgery in comparison to those who did not undergo surgery.

“How this change in glucagon after gastric alters glucose metabolism remains to be known,” she says. “However, in understanding these mechanisms, we hope to come up with less invasive surgical procedures or medical treatment to treat

Provided by University of Cincinnati (news : web)

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Article source: http://www.physorg.com/news/2011-09-reveals-hormone-action-treatments-diabetes.html

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Sep 302011
 



Humans, sharks share immune-system feature

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A central element of the immune system has remained constant through more than 400 million years of evolution, according to new research at National Jewish Health. In the September 29, 2011, online version of the journal Immunity, the researchers report that T-cell receptors from mice continue to function even when pieces of shark, frog and trout receptors are substituted in. The function of the chimeric receptors depends on a few crucial amino acids, found also in humans, that help the T-cell receptor bind to MHC molecules presenting antigens.


“These findings prove a hypothesis first proposed 40 years ago,” said senior author Laurent Gapin, PhD, associate professor of immunology in the Integrated Deparemtn of Immunology at National Jewish Health and the University of Colorado Denver. “Even though mammals, amphibians and cartilaginous fish last shared a common ancestor more than 400 million years ago, they continue to share an element of their T-cell receptors, indicating that the T cell-MHC interaction arose early in the of the immune system, and is central to its function.”

The T cell serves as the sentinel, manager and enforcer of the adaptive immune response. It relies on its receptor, the T-cell receptor, to recognize foreign material and identify the target of the immune-system attack. When the receptor binds to small fragments of foreign organisms, called antigens, the T cell becomes activated, proliferates and initiates an attack against any molecule or organism containing that antigen.

T cells, however, cannot recognize free-floating antigens. They recognize antigens only when they are held by MHC on the surfaces of other cells, much as a hotdog bun (MHC molecule) holds a hotdog (antigen). This interaction between the T cell and MHC molecules is crucial for immune defense and organ transplants. Compatibility of transplanted organs is determined by the similarity of different people’s MHC molecules. Nonetheless, this interaction has long mystified scientists and is poorly understood.

In 1971 future Nobel Laureate Niels K. Jerne proposed that evolution might have selected for genes that specifically recognize MHC molecules. Evidence discovered later suggested T cells’ affinity for MHC molecules might instead be the product of development that occurs as T cells mature in the thymus. The question remained unanswered for 40 years.

The T-cell receptor is constructed by piecing together several peptides among dozens that are available, plus a few random amino acid sequences. This combination is what allows the to generate an almost infinite variety of receptors capable of recognizing almost any potential invader. The receptor has six loops that are the primary binding points for the antigen-MHC complex. One of those loops, known as CDR2, frequently binds the MHC molecule.

Searching for possible similarities in T-cell receptors of different animals, the researchers compared the amino acid sequences of one segment of the T-cell receptor containing the CDR2 loop. Although the segments contained less than 30 percent of the same , two specific amino acids were the same in human, mouse, frog, trout and shark T-cell receptors. Those appeared to be amino acids specifically involved in binding to the MHC molecule.

“The evolutionary inheritance of this pattern goes all the way from sharks to humans, which last shared a common ancestor 450 million years ago,” said co-author Philippa Marrack, PhD.

The researchers then inserted segments containing the CDR2 loop from frog, trout and shark T-cell receptors into mouse cells. These chimeric T-cell receptors recognized antigen bound to a mouse MHC molecule.

Since sections of , and shark T-cell receptors functioned perfectly well in T-cell , the experiments suggested that the T-cell’s ability to see an antigen only when complexed with an MHC molecule first arose more than 400 million years ago, when all four animals shared a .

Provided by National Jewish Health

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Article source: http://www.physorg.com/news/2011-09-humans-sharks-immune-system-feature.html

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Sep 302011
 



Cosmic weight watching reveals black hole-galaxy history

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Colors in this image of the galaxy J090543.56+043347.3 indicate whether there is gas moving towards us or away from us, and at what speed. Using this information, the researchers reconstructed the galaxys dynamical mass. The star shape indicates the position of the galaxys active nucleus; the surrounding contour lines indicate brightness levels for light emitted by the nucleus. Dark blue pixels indicate gas moving towards us at a speed of 250 km/s, dark red pixels gas moving away from us at 350 km/s. Credit: K. J. Inskip/MPIA

(PhysOrg.com) — Using state-of-the-art technology and sophisticated data analysis tools, a team of astronomers from the Max Planck Institute for Astronomy has developed a new and powerful technique to directly determine the mass of an active galaxy at a distance of nearly 9 billion light-years from Earth. This pioneering method promises a new approach for studying the co-evolution of galaxies and their central black holes. First results indicate that for galaxies, the best part of cosmic history was not a time of sweeping changes.


One of the most intriguing developments in astronomy over the last few decades is the realization that not only do most contain central black holes of gigantic size, but also that the mass of these central black holes are directly related to the mass of their . This correlation is predicted by the current of , the so-called hierarchical model, as from the Max Planck Institute for Astronomy have recently shown.

When astronomers look out to greater and greater distances, they look further and further into the past. Investigating this black hole-galaxy mass correlation at different distances, and thus at different times in , allows astronomers to study galaxy and black hole evolution in action.

For galaxies further away than 5 billion light-years (corresponding to a redshift of z 0.5), such studies face considerable difficulties. The typical objects of study are so-called active galaxies, and there are well-established methods to estimate the mass of such a galaxy’s central black hole. It is the galaxy’s mass itself that is the challenge: At such distances, standard methods of estimating a galaxy’s mass become exceedingly uncertain or fail altogether.

Now, a team of astronomers from the Max Planck Institute for Astronomy, led by Dr. Katherine Inskip, has, for the first time, succeeded in directly “weighing” both a galaxy and its central black hole at such a great distance using a sophisticated and novel method. The galaxy, known to astronomers by the number J090543.56+043347.3 (which encodes the galaxy’s position in the sky) has a distance of 8.8 billion light-years from Earth (redshift z = 1.3).


Cosmic weight watching reveals black hole-galaxy history
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In ordinary images such as this one from the Sloan Digital Survey, J090543.56+043347.3 appears as a featureless blob of light. Credit: Sloan Digital Sky Survey

The astronomers succeeded in measuring directly the so-called dynamical mass of this active galaxy. The key idea is the following: A galaxy’s stars and gas clouds orbit the galactic centre; for instance, our Sun orbits the centre of the Milky Way galaxy once every 250 million years. The stars’ different orbital speeds are a direct function of the galaxy’s mass distribution. Determine orbital speeds and you can determine the galaxy’s total mass.

This is much easier said than done. In order to secure their measurement, the cosmic weightwatchers had to pull out all the stops of observational astronomy before finally obtaining a reliable value for the dynamical mass of J090543.56+043347.3. Combining this result with the mass value of the galaxy’s central black hole, which the researchers measured from the same dataset, the result is the same that would be expected for a present-day galaxy. Apparently, nothing major has changed between now and then: At least out to this distance, 9 billion years into the past, the correlation between galaxies and their appears to be the same as for their modern-day counterparts.

Inskip and her colleagues are already hard at work to expand their novel kind of analysis to a larger set of 15 further galaxies. If this confirms their conclusions from J090543.56+043347.3, that would indicate that, over the past 9 billion years – for more than half of the age of our Universe! – most galaxies have lived comparatively boring lives, subject to only very limited and slow change.

More information: K. J. Inskip, et al., Resolving the Dynamical Mass of a z ~ 1.3 Quasi-stellar Object Host Galaxy Using SINFONI and Laser Guide Star Assisted Adaptive Optics, Astrophysical Journal, Volume 739, Issue 2, article id. 90 (2011)

Provided by Max-Planck-Gesellschaft (news : web)

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Article source: http://www.physorg.com/news/2011-09-cosmic-weight-reveals-black-hole-galaxy.html

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Scientists construct, to maintain complementary DNA libraries of first lizard genome sequence

Enlarge The cDNA libraries of the North American green anole lizard, the first non-avian reptile to have its genome sequenced, will be housed at IU and made available to researchers around the world. Credit: David E. Scott, Savannah River Ecology Laboratory, Aiken, SC, USA Scientists at Indiana University Bloomington’s Center for Genomics and Bioinformatics are credited with constructing the cDNA libraries for the first-ever genome sequence of a non-bird reptile, the North American green anole lizard (Anolis carolinensis). The genome [Read More]

Swallowing ‘button batteries’ can lead to serious injuries or death

(Medical Xpress) — Small, coin-sized batteries can cause serious health problems and can even lead to death if swallowed by children, and Monroe Carell Jr. Children’s Hospital at Vanderbilt wants to educate parents and caregivers on the issue. In the past six years, 11 children nationwide have died after swallowing “button batteries,” which can be found in remote controls, calculators, watches, key chains, bathroom scales and musical greeting cards. Emergency doctors at Children’s Hospital encounter these cases regularly. According to [Read More]

The internet of tomorrow: Faster, better and cheaper

A researcher in the College of Optical Sciences prepares an experimental setup for testing data transmission using light. Credit: College of Optical Sciences The UA, USC and other institutions are building the future of communications using light. Researchers from the University of Arizona, the University of Southern California and seven other institutions are attempting to save the Internet by making it cheaper, faster and better. With the rising demand for Internet access outstripping the existing Internet capacity, scientists are turning [Read More]

Medical packaging can make the difference

Enlarge Practitioners prepare for an operating room simulation done for 15 packaging professionals during the School of Packaging’s Packaging Immersion Experience pilot program held in October 2010 at MSU’s Learning and Assessment Center. Courtesy photo (Medical Xpress) — At the site of a car crash, in an emergency room or at an operating table: The seconds it takes to get a medical device to work properly or to understand the packaging on a device can be a matter of life and [Read More]

What makes a thinker?

Enlarge In a lecture at the Harvard Graduate School of Education, Professor David Perkins explored the evolution of the teaching of thinking, including its history, obstacles, advances, and likely future. Credit: Rose Lincoln/Harvard Staff Photographer The notion of teaching people to become better thinkers is such a basic concept that most people would assume the goal has always been a vital part of educators’ tool kits. But the concept is fairly new on the education landscape, said the man who [Read More]

Vladimir Putin and the 22nd Amendment

Vladimir Putin’s recent announcement that he intends to return to the presidency after the 2012 election has been rightly denounced as a deepening of authoritarianism in Russia. Having effectively repressed Russia’s opposition parties and media, Putin is now consolidating his position as a dictator. Barring some sort of sudden collapse of his regime (which is by no means impossible), he can now rule into the 2020s with little or no effective opposition. It’s worth remembering that Putin had to leave [Read More]